Biologics are a class of therapeutic substances composed of large and complex “macromolecules.” Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular, or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug’s efficacy. Thus there are many research efforts that seek to make it possible to successfully deliver a broad set of biologics by mouth. The goal of my team’s research was to employ needleless delivery, or jetting, as an approach to the above problem. Our work included mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, and development of a jetting pill capable of autonomous drug delivery. We eventually used our jetting pill to deliver substantial quantities of insulin to the gastric mucosa in vivo (using pigs as a large-animal model).