This device was designed to assist with the characterization of jet injection performance across multiple tissue types. The device was triggered by a ball-detent mechanism and had a removable ampule which allowed for quick refilling of the fluid payload between shots. Pressure was applied to the fluid either by a pneumatic cylinder or a spring. (Use of a pneumatic cylinder is preferable in ex vivo experiments as the pressure input can be easily adjusted to generate different output performance, while use of a spring is preferable during in vivo use, where portability is of greater importance). Aside from the device itself, we also designed a test-stand to directly measure the jetting force of the hand-held device.